Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Investigation

Posted by DaveB on décembre 30, 2016

Lee, Baek, Park, Kim, Tussupbayev, Kim, Baik, Cho, J. Am. Chem. Soc. 2016, online publication [10.1021/jacs.6b11757]

One-Step Transformation of Trichloroacetamide into Isonitrile

Posted by DaveB on décembre 29, 2016

Adachi, Miyasaka, Hashimoto, Nishikawa, Org. Lett. 2016, online publication [10.1021/acs.orglett.6b03583]

Umpolung Addition of Aldehydes to Aryl Imines

Posted by DaveB on décembre 27, 2016

Chen, Dai, Wang, Li, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201610578]

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

Posted by DaveB on décembre 26, 2016

Seo, Katcher, Jamison, Nat. Chem. 2016, online publication [10.1038/nchem.2690]

Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals

Posted by DaveB on décembre 23, 2016

Zhou, Ma, Behnke, Gao, Kürti, J. Am. Chem. Soc. 2016, online publication [10.1021/jacs.6b12712]

A Convenient Method for Catalytic Aromatic Pentafluoroethylation Using Potassium (Pentafluoroethyl)trimethoxyborate

Posted by DaveB on décembre 22, 2016

Sugiishi, Kawauchi, Sato, Sakai, Amii, Synthesis 2016, online publication [10.1055/s-0036-1588131]

Recent Advances in Scaffold Hopping

Posted by DaveB on décembre 21, 2016

Hu, Stumpfe, Bajorath, J. Med. Chem. 2016, online publication [10.1021/acs.jmedchem.6b01437]

Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant

Posted by DaveB on décembre 19, 2016

Yi, Niu, Song, Li, Dou, Singh, Lei, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201609274]

A Robust and Broadly Applicable Cobalt-Catalyzed Cross-Coupling of Functionalized Bench-Stable Organozinc Pivalates with Unsaturated Halides

Posted by DaveB on décembre 16, 2016

Hammann, Lutter, Haas, Knochel, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201610324]

When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?

Posted by DaveB on décembre 16, 2016

Malhotra, Karanicolas, J. Med. Chem. 2016, online publication [10.1021/acs.jmedchem.6b00725]

Method for Accessing Nitrogen-Containing, B -Heteroaryl-Substituted 2,1-Borazaronaphthalenes

Posted by DaveB on décembre 15, 2016

Davies, Zhou, Jouffroy, Molander, J. Org. Chem. 2016, online publication [10.1021/acs.joc.6b02574]

Continuous Flow Synthesis and Purification of Aryldiazomethanes through Hydrazone Fragmentation

Posted by DaveB on décembre 09, 2016

Lévesque, Laporte, Charette, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201608444]

Efficient Synthesis of Trifluoromethyl Amines through a Formal Umpolung Strategy from the Bench-Stable Precursor (Me4N)SCF3

Posted by DaveB on décembre 09, 2016

Scattolin, Deckers, Schoenebeck, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201609480]

Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

Posted by DaveB on décembre 07, 2016

Llanes, Rodríguez-escrich, Sayalero, Pericàs, Org. Lett. 2016, 18(24), 6292-6295 [10.1021/acs.orglett.6b03156]

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Novel Organic Synthesis through Ultrafast Chemistry

Posted by DaveB on décembre 06, 2016

Wirth, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201609595]

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Posted by DaveB on décembre 05, 2016

Wang, Dai, Li, Nat. Chem. 2016, online publication [10.1038/NCHEM.2677]

Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

Posted by DaveB on novembre 30, 2016

Gutmann, Cantillo, Weigl, Cox, Kappe, Eur. J. Org. Chem. 2016, online publication [10.1002/ejoc.201601453]

Visible-Light-Promoted Activation of Unactivated C(sp 3 )–H Bonds and Their Selective Trifluoromethylthiolation

Posted by DaveB on novembre 28, 2016

Mukherjee, Maji, Tlahuext-aca, Glorius, J. Am. Chem. Soc. 2016, 138(50), 16200-16203 [10.1021/jacs.6b09970]

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Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines

Posted by DaveB on novembre 28, 2016

Bonazaba Milandou, Carreyre, Alazet, Greco, Martin-mingot, Nkounkou Loumpangou, Ouamba, Bouazza, Billard, Thibaudeau, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201609574]

Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective

Posted by DaveB on novembre 22, 2016

Sautier, Nising, Wortmann, Angew. Chem. Int. Ed. 2016, 55(52), 15982-15988 [10.1002/anie.201608270]

Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process

Posted by DaveB on novembre 22, 2016

D’attoma, Camara, Brun, Robin, Bostyn, Buron, Routier, Org. Process Res. Dev. 2016, online publication [10.1021/acs.oprd.6b00318]

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Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow

Posted by DaveB on novembre 17, 2016

Delano, Bandarage, Palaychuk, Green, Boyd, J. Org. Chem. 2016, 81(24), 12525-12531 [10.1021/acs.joc.6b02408]

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Continuous-Flow Diazotization for Efficient Synthesis of Methyl 2-(Chlorosulfonyl)benzoate: An Example of Inhibiting Parallel Side Reactions

Posted by DaveB on novembre 17, 2016

Yu, Dong, Xie, Liu, Su, Org. Process Res. Dev. 2016, 20(12), 2116-2123 [10.1021/acs.oprd.6b00238]

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Decarboxylative Peptide Macrocyclization through Photoredox Catalysis

Posted by DaveB on novembre 17, 2016

Mccarver, Qiao, Carpenter, Borzilleri, Poss, Eastgate, Miller, Macmillan, Angew. Chem. Int. Ed. 2016, online publication [10.1002/anie.201608207]

Effect of Bronsted Acids and Bases, and Lewis Acid (Sn2+) on the Regiochemistry of the Reaction of Amines with Trifluoromethyl-β-diketones: Reaction of 3-Aminopyrrole to Selectively Produce Regioisomeric 1H-Pyrrolo[3,2-b]pyridines

Posted by DaveB on novembre 17, 2016

De Rosa, Arnold, Hartline, Truong, Verner, Wang, Westin, J. Org. Chem. 2015, 80(24), 12288-12299 [10.1021/acs.joc.5b02192]

AlkylFluor: Deoxyfluorination of Alcohols

Posted by DaveB on novembre 16, 2016

Goldberg, Shen, Li, Ritter, Org. Lett. 2016, 18(23), 6102-6104 [10.1021/acs.orglett.6b03086]

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Recent Developments in Amide Synthesis Using Nonactivated Starting Materials

Posted by DaveB on novembre 15, 2016

Ojeda-porras, Gamba-sánchez, J. Org. Chem. 2016, 81(23), 11548-11555 [10.1021/acs.joc.6b02358]

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Practical Photocatalytic Trifluoromethylation and Hydrotrifluoromethylation of Styrenes in Batch and Flow

Posted by DaveB on novembre 15, 2016

Straathof, Cramer, Hessel, Noël, Angew. Chem. Int. Ed. 2016, 55(50), 15549-15553 [10.1002/anie.201608297]

Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Effect of TESCF3 as an Additive

Posted by DaveB on novembre 15, 2016

Ye, Takada, Buchwald, Angew. Chem. Int. Ed. 2016, 55(50), 15559-15563 [10.1002/anie.201608927]

Metal-Free Aromatic Carbon–Phosphorus Bond Formation via a Sandmeyer-Type Reaction

Posted by DaveB on novembre 07, 2016

Wang, Qiu, Mo, Zhang, Wang, J. Org. Chem. 2016, 81(23), 11603-11611 [10.1021/acs.joc.6b01820]

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Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones

Posted by DaveB on novembre 01, 2016

Skillinghaug, Rydfjord, Sävmarker, Larhed, Org. Process Res. Dev. 2016, online publication [10.1021/acs.oprd.6b00306]

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Direct assembly of multiply oxygenated carbon chains by decarbonylative radical–radical coupling reactions

Posted by DaveB on octobre 31, 2016

Masuda, Nagatomo, Inoue, Nat. Chem. 2016, online publication [10.1038/nchem.2639]

Optimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm

Posted by DaveB on octobre 28, 2016

Cortés-borda, Kutonova, Jamet, Trusova, Zammattio, Truchet, Rodriguez-zubiri, Felpin, Org. Process Res. Dev. 2016, online publication [10.1021/acs.oprd.6b00310]

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Phosphonate Biochemistry

Posted by DaveB on octobre 27, 2016

Horsman, Zechel, Chem. Rev. 2016, online publication [10.1021/acs.chemrev.6b00536]

Generation, Stability, and Utility of Lithium 4,4′-Di-tert-butylbiphenylide (LiDBB)

Posted by DaveB on octobre 27, 2016

Hill, Rychnovsky, J. Org. Chem. 2016, 81(22), 10707-10714 [10.1021/acs.joc.6b01748]

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Copper-Catalyzed Aerobic Oxidative Amidation of Benzyl Alcohols

Posted by DaveB on octobre 24, 2016

Krabbe, Chan, Franczyk, Shekhar, Napolitano, Presto, Simanis, J. Org. Chem. 2016, 81(22), 10688-10697 [10.1021/acs.joc.6b01686]

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N -Cyanation of Secondary Amines Using Trichloroacetonitrile

Posted by DaveB on octobre 18, 2016

Ayres, Ling, Morrill, Org. Lett. 2016, 18(21), 5528-5531 [10.1021/acs.orglett.6b02775]

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Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight

Posted by DaveB on octobre 13, 2016

Lefebvre, Synlett 2016, 28(01), 19-23 [10.1055/s-0036-1588643]

Role of Fluoride Ions in Palladium-Catalyzed Cross-Coupling Reactions­

Posted by DaveB on octobre 13, 2016

Grimaud, Jutand, Synthesis 2016, online publication [10.1055/s-0036-1588648]

Direct (Hetero)arylation Reactions of (Hetero)arenes as Tools for the Step- and Atom-Economical Synthesis of Biologically Active Unnatural Compounds Including Pharmaceutical Targets

Posted by DaveB on octobre 11, 2016

Rossi, Lessi, Manzini, Marianetti, Bellina, Synthesis 2016, 48(22), 3821-3862 [10.1055/s-0036-1588303]